2023	2022	2021	2020
2019	2018	2017	2016	2015
2014	2013	2012	2011	2010

2022

Nishida Y, Yanagisawa S, Morita R, Shigematsu H, Shinzawa-Itoh K, Yuki H, Ogasawara S, Shimuta K, Iwamoto T, Nakabayashi C, Matsumura W, Kato H, Gopalasingam C, Nagao T, Qaqorh T, Takahashi Y, Yamazaki S, Kamiya K, Harada R, Mizuno N, Takahashi H, Akeda Y, Ohnishi M, Ishii Y, Kumasaka T, Murata T, Muramoto K, Tosha T, Shiro Y, Honma T, Shigeta Y, Kubo M, Takashima S, Shintani Y. Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.
Nat Commun. 2022;13(1):7591. doi: 10.1038/s41467-022-34771-y. PMID: 36481732

Kato M, Sano R, Yoshida N, Iwafuji M, Nishiyama Y, Oka S, Shinzawa-Itoh K, Nishida Y, Shintani Y, Yagi I. Effects of Interfacial Interactions on Electrocatalytic Activity of Cytochrome c Oxidase in Biomimetic Lipid Membranes on Gold Electrodes.
J Phys Chem Lett. 2022;13(39):9165-9170. doi: 10.1021/acs.jpclett.2c01765. PMID: 36166647

 

2021

Miyashita Y, Tsukamoto O, Matsuoka K, Kamikubo K, Kuramoto Y, Ying Fu H, Tsubota T, Hasuike H, Takayama T, Ito H, Hitsumoto T, Okamoto C, Kioka H, Oya R, Shinomiya H, Hakui H, Shintani Y, Kato H, Kitakaze M, Sakata Y, Asano Y, Takashima S. The CR9 element is a novel mechanical load-responsive enhancer that regulates natriuretic peptide genes expression.
FASEB J. 2021;35(4):e21495. doi: 10.1096/fj.202002111RR. PMID: 33689182

Yashirogi S, Nagao T, Nishida Y, Takahashi Y, Qaqorh T, Yazawa I, Katayama T, Kioka H, Matsui TS, Saito S, Masumura Y, Tsukamoto O, Kato H, Ueda H, Yamaguchi O, Yashiro K, Yamazaki S, Takashima S, Shintani Y. AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170.
EMBO Rep. 2021;22(1):e50949. doi: 10.15252/embr.202050949. PMID: 33251722

 

2020

Nagao T, Shintani Y, Hayashi T, Kioka H, Kato H, Nishida Y, Yamazaki S, Tsukamoto O, Yashirogi S, Yazawa I, Asano Y, Shinzawa-Itohe K, Imamura H, Suzuki T, Suzuki T, Goto Y, Takashima S.
Higd1a improves respiratory function in the models of mitochondrial disorder.
FASEB J. 2020;34(1):1859-1871

Kioka H, Kato H, Fujita T, Asano Y, Shintani Y, Yamazaki S, Tsukamoto O, Imamura H, Kogo M, Kitakaze M, Sakata Y, Takashima S.
In vivo real-time ATP imaging in zebrafish hearts reveals G0s2 induces ischemic tolerance
FASEB J. 2020;34(2):2041-2054. doi: 10.1096/fj.201901686R.

 

2019

Saba R, Kitajima K, Rainbow L, Engert S, Uemura M, Ishida H, Kokkinopoulos I, Shintani Y, Miyagawa S, Kanai Y, Kanai-Azuma M, Koopman P, Meno C, Kenny J, Lickert H, Saga Y, Suzuki K, Sawa Y, Yashiro K.
Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice.
Sci Rep. 2019 Aug 16;9(1):11953. doi: 10.1038/s41598-019-48321-y.

Kamikubo K, Kato H, Kioka H, Yamazaki S, Tsukamoto O, Nishida Y, Asano Y, Imamura H, Kawahara H, Shintani Y, Takashima S.
A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2.
J Biol Chem. 2019 Oct 4;294(40):14562-14573. doi: 10.1074/jbc.RA119.008544. Epub 2019 Aug 1.

Takahashi Y, Kioka H, Shintani Y, Ohki A, Takashima S, Sakata Y, Higuchi T, Saito S.
Detection of increased intracerebral lactate in a mouse model of Leigh syndrome using proton MR spectroscopy.
Magn Reson Imaging. 2019 May;58:38-43. doi: 10.1016/j.mri.2019.01.010. Epub 2019 Jan 19.

Saito S, Takahashi Y, Ohki A, Shintani Y, Higuchi T.
Early detection of elevated lactate levels in a mitochondrial disease model using chemical exchange saturation transfer (CEST) and magnetic resonance spectroscopy (MRS) at 7T-MRI.
Radiol Phys Technol. 2019 Mar;12(1):46-54. doi: 10.1007/s12194-018-0490-1. Epub 2018 Nov 22.

A dipeptidyl peptidase-IV inhibitor improves diastolic dysfunction in Dahl salt-sensitive rats.
Nakajima Y, Ito S, Asakura M, Min KD, Fu HY, Imazu M, Hitsumoto T, Takahama H, Shindo K, Fukuda H, Yamazaki S, Asanuma H, Kitakaze M.
J Mol Cell Cardiol. 2019 Apr;129:257-265. doi: 10.1016/j.yjmcc.2019.03.009. Epub 2019 Mar 14.

Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation.
Yamada N, Asano Y, Fujita M, Yamazaki S, Inanobe A, Matsuura N, Kobayashi H, Ohno S, Ebana Y, Tsukamoto O, Ishino S, Takuwa A, Kioka H, Yamashita T, Hashimoto N, Zankov DP, Shimizu A, Asakura M, Asanuma H, Kato H, Nishida Y, Miyashita Y, Shinomiya H, Naiki N, Hayashi K, Makiyama T, Ogita H, Miura K, Ueshima H, Komuro I, Yamagishi M, Horie M, Kawakami K, Furukawa T, Koizumi A, Kurachi Y, Sakata Y, Minamino T, Kitakaze M, Takashima S.
Circulation. 2019 Apr 30;139(18):2157-2169. doi: 10.1161/CIRCULATIONAHA.118.036761.

Miyata H, Imai H, Koseki H, Shimizu K, Abekura Y, Oka M, Kawamata T, Matsuda T, Nozaki K, Narumiya S, Aoki T.
Vasa vasorum formation is associated with rupture of intracranial aneurysms.
J Neurosurg. 2019 Aug 16:1-11. doi: 10.3171/2019.5.JNS19405. [Epub ahead of print]

Aoki T, Miyata H, Abekura Y, Koseki H, Shimizu K.
Rat Model of Intracranial Aneurysm: Variations, Usefulness, and Limitations of the Hashimoto Model.
Acta Neurochir Suppl. 2020;127:35-41. doi: 10.1007/978-3-030-04615-6_6.

Shimizu K, Miyata H, Abekura Y, Oka M, Kushamae M, Kawamata T, Mizutani T, Kataoka H, Nozaki K, Miyamoto S, Aoki T.
High-Fat Diet Intake Promotes the Enlargement and Degenerative Changes in the Media of Intracranial Aneurysms in Rats.
J Neuropathol Exp Neurol. 2019 Sep 1;78(9):798-807. doi: 10.1093/jnen/nlz057.

Aoki T, Koseki H, Miyata H, Itoh M, Kawaji H, Takizawa K, Kawashima A, Ujiie H, Higa T, Minamimura K, Kimura T, Kasuya H, Nozaki K, Morita A, Sano H, Narumiya S.
RNA sequencing analysis revealed the induction of CCL3 expression in human intracranial aneurysms.
Sci Rep. 2019 Jul 17;9(1):10387. doi: 10.1038/s41598-019-46886-2.

Frösen J, Cebral J, Robertson AM, Aoki T.
Flow-induced, inflammation-mediated arterial wall remodeling in the formation and progression of intracranial aneurysms.
Neurosurg Focus. 2019 Jul 1;47(1):E21. doi: 10.3171/2019.5.FOCUS19234.

Shimizu K, Kushamae M, Aoki T.
Macrophage Imaging of Intracranial Aneurysms.
Neurol Med Chir (Tokyo). 2019 Jul 15;59(7):257-263. doi: 10.2176/nmc.st.2019-0034. Epub 2019 May 11.

Oka M, Kushamae M, Aoki T, Yamaguchi T, Kitazato K, Abekura Y, Kawamata T, Mizutani T, Miyamoto S, Takagi Y.
KRAS G12D or G12V Mutation in Human Brain Arteriovenous Malformations.
World Neurosurg. 2019 Jun;126:e1365-e1373. doi: 10.1016/j.wneu.2019.03.105. Epub 2019 Mar 19.

Shimizu K, Kushamae M, Mizutani T, Aoki T.
Intracranial Aneurysm as a Macrophage-mediated Inflammatory Disease.
Neurol Med Chir (Tokyo). 2019 Apr 15;59(4):126-132. doi: 10.2176/nmc.st.2018-0326. Epub 2019 Mar 14.

Koseki H, Miyata H, Shimo S, Ohno N, Mifune K, Shimano K, Yamamoto K, Nozaki K, Kasuya H, Narumiya S, Aoki T.
Two Diverse Hemodynamic Forces, a Mechanical Stretch and a High Wall Shear Stress, Determine Intracranial Aneurysm Formation.
Transl Stroke Res. 2019 Feb 8. doi: 10.1007/s12975-019-0690-y. [Epub ahead of print]

 

2018

Kobayashi K, Ichihara Y, Tano N, Fields L, Murugesu N, Ito T, Ikebe C, Lewis F, Yashiro K, Shintani Y, Uppal R, Suzuki K.
Fibrin Glue-aided, Instant Epicardial Placement Enhances the Efficacy of Mesenchymal Stromal Cell-Based Therapy for Heart Failure.
Sci Rep. 2018 Jun 21;8(1):9448. doi: 10.1038/s41598-018-27881-5.

Mori D, Matsui I, Shimomura A, Hashimoto N, Matsumoto A, Shimada K, Yamaguchi S, Oka T, Kubota K, Yonemoto S, Sakaguchi Y, Takahashi A, Shintani Y, Takashima S, Takabatake Y, Hamano T, Isaka Y.
Protein carbamylation exacerbates vascular calcification.
Kidney Int. 2018 Jul;94(1):72-90. doi: 10.1016/j.kint.2018.01.033. Epub 2018 Apr 30.

 

Calum Robb, Henry McSorley, Jinju Lee, Tomohiro Aoki, Cunjing Yu, Siobhan Crittenden, Anne Astier, Jennifer Felton, Nicholas Parkinson, Adane Ayele, Richard Breyer, Stephen Anderton, Shuh Narumiya, Adriano Rossi, Sarah Howie, Emma Guttman-Yassky, Richard Weller, Chengcan Yao
Prostaglandin E2 stimulates adaptive IL-22 production and promotes allergic contact dermatitis.
J Allergy Clin Immunol. 141(1):152-162, 2018. doi: 10.1016/j.jaci.2017.04.045.

 

2017

Ikeda K, Kinoshita M, Kayama H, Nagamori S, Kongpracha P, Umemoto E, Okumura R, Kurakawa T, Murakami M, Mikami N, Shintani Y, Ueno S, Andou A, Ito M, Tsumura H, Yasutomo K, Ozono K, Takashima S, Sakaguchi S, Kanai Y, Takeda K.
Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells.
Cell Rep. 2017 Nov 14;21(7):1824-1838. doi: 10.1016/j.celrep.2017.10.082.

 

Aoki T, Narumiya S
Prostaglandin E2-EP2 signaling as a node of chronic inflammation in the colon tumor microenvironment.
Inflammation and Regeneration 37: 4, 2017.DOI; 10.1186/s41232-017-0036-7

Aoki T, R.Yamamoto, Narumiya S
Targeting macrophages to treat intracranial aneurysm.
Oncotarget 28;8(62):104704-104705, 2017.doi: 10.18632/oncotarget.21368.

Rie Yamamoto, Tomohiro Aoki, Hirokazu Koseki, Miyuki Fukuda, Jun Hirose, Keiichi Tsuji, Katsumi Takizawa, Shinichiro Nakamura, Haruka Miyata, Nozomu Hamakawa, Hidetoshi Kasuya, Kazuhiko Nozaki, Yoshitaka Hirayama, Ichiro Aramori, Shuh Narumiya
An S1P1 agonist, ASP4058, suppresses intracranial aneurysm progression through promoting endothelial integrity and blocking macrophage transmigration.
British Journal of Pharmacology 174(13):2085-2101, 2017.doi: 10.1111/bph.13820.

Haruka Miyata, Hirokazu Koseki, Katsumi Takizawa, Hidetoshi Kasuya, Kazuhiko Nozaki, Shuh Narumiya, Tomohiro Aoki
T cell function is dispensable for intracranial aneurysm formation and progression.
PLoS ONE 12(4):e0175421, 2017gt.doi: 10.1371/journal.pone.0175421.

Tomohiro Aoki, Juhana Frosen, Miyuki Fukuda, Kana Bando, Go Shioi, Keiichi
Tsuji, Eliisa Ollikainen, Kazuhiko Nozaki, Johanna Laakkonen, Shuh Narumiya
Prostaglandin E2-EP2-NF-kB signaling in macrophages as a potential therapeutic
target of intracranial aneurysm.
Science Signaling 10, eaah6037, 2017.DOI; 10.1126/scisignal.aah6037

Tomohiro Aoki, Makoto Saito, Hirokazu Koseki, Keiichi Tsuji, Atsushi Tsuji, Kiyoshi Murata, Hidetoshi Kasuya, Akio Morita, Shuh Narumiya, Kazuhiko Nozaki; for MR macrophage imaging study investigators
Macrophage imaging of cerebral aneurysms with ferumoxytol: an exploratory study in an animal model and in patients
J Stroke Cerebrovasc Dis. 26(10):2055-2064, 2017.doi: 10.1016/j.jstrokecerebrovasdis.2016.10.026.

Taichi Ikedo, Manabu Minami; Hiroharu Kataoka, Kosuke Hayashi; Manabu Nagata; Risako Fujikawa; Sei Higuchi; Mika Yasui; Tomohiro Aoki; Miyuki Fukuda; Masayuki Yokode; Susumu Miyamoto
Dipeptidyl Peptidase-4 inhibitor Anagliptin prevents intracranial aneurysm growth by suppressing macrophage infiltration and activation.
Journal of the American Heart Association 19;6(6), 2017. pii: e004777.doi: 10.1161/JAHA.116.004777.

Tze Mun Loo, Fumitaka Kamachi, Yoshihiro Watanabe, Shin Yoshimoto, Hiroaki Kanda, Yuriko Arai, Yaeko Nakajima-Takagi, Atsushi Iwama, Tomoaki Koga, Yukihiko Sugimoto, Takayuki Ozawa, Nasaru Nakamura, Miho Kumagai, Koichi Watashi, Makoto M. Taketo, Tomohiro Aoki, Shuh Narumiya, Masanobu Oshima, Makoto Arita, Eiji Hara, Naoko Ohtani
Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated
suppression of antitumor immunity.
Cancer Discovery 7(5):522-538, 2017.doi: 10.1158/2159-8290

 

2016

Nishida Y, Ikeya T, Mikawa T, Inoue J, Ito Y, Shintani Y, Masui R, Kuramitsu S, Takashima S.
A specific single-stranded DNA induces a distinct conformational change in the nucleoid-associated protein HU.
Biochem Biophys Rep. 2016 Oct 11;8:318-324. doi: 10.1016/j.bbrep.2016.09.014. eCollection 2016 Dec

Campbell NG, Kaneko M, Shintani Y, Narita T, Sawhney V, Coppen SR, Yashiro K, Mathur A, Suzuki K.
Cell Size Critically Determines Initial Retention of Bone Marrow Mononuclear Cells in the Heart after Intracoronary Injection: Evidence from a Rat Model.
PLoS One. 2016 Jul 5;11(7):e0158232. doi: 10.1371/journal.pone.0158232. eCollection 2016.

Masumura Y, Higo S, Asano Y, Kato H, Yan Y, Ishino S, Tsukamoto O, Kioka H, Hayashi T, Shintani Y, Yamazaki S, Minamino T, Kitakaze M, Komuro I, Takashima S, Sakata Y.
Btg2 is a Negative Regulator of Cardiomyocyte Hypertrophy through a Decrease in Cytosolic RNA.
Sci Rep. 2016 Jun 27;6:28592. doi: 10.1038/srep28592.

Shiraishi M, Shintani Y, Shintani Y, Ishida H, Saba R, Yamaguchi A, Adachi H, Yashiro K, Suzuki K.
Alternatively activated macrophages determine repair of the infarcted adult murine heart.
J Clin Invest. 2016 Jun 1;126(6):2151-66. doi: 10.1172/JCI85782. Epub 2016 May 3.

Tano N, Kaneko M, Ichihara Y, Ikebe C, Coppen SR, Shiraishi M, Shintani Y, Yashiro K, Warrens A, Suzuki K.
Allogeneic Mesenchymal Stromal Cells Transplanted Onto the Heart Surface Achieve Therapeutic Myocardial Repair Despite Immunologic Responses in Rats.
J Am Heart Assoc. 2016 Feb 18;5(2). pii: e002815. doi: 10.1161/JAHA.115.002815.

 

Koseki H., Aoki T
Population of inflammatory cells in intracranial aneurysm with the special insight to the development of novel diagnostic and therapeutic approaches.
Neuroimmunology and Neuroinflammation 3;173-179, 2016

Aoki T, Nozaki K
Preemptive medicine for cerebral aneurysm.
Neurologia Medico-Chirurgica 56(9):552-568, 2016.DOI: 10.2176/nmc.st.2016-0063

Xiaojun Ma, Tomohiro Aoki, Shuh Narumiya
Prostaglandin E2-EP4 signaling persistently amplifies CD40-mediated induction of IL-23 p19 expression through canonical and non-canonical NF-kB pathways.
Cellular and Molecular Immunology 13(2):240-250, 2016.doi: 10.1038/cmi.2015.70.

Tomohiro Aoki, Kimiko Yamamoto, Miyuki Fukuda, Yuji Shimogonya, Shunichi
Fukuda, Shuh Narumiya
Sustained expression of MCP-1 by low wall shear stress loading concomitant with
turbulent flow on endothelial cells of intracranial aneurysm.
Acta Neuropathologica Communications 4(1):48, 2016.DOI: 10.1186/s40478-016-0318-3

 

2015

Kokkinopoulos I, Ishida H, Saba R, Ruchaya P, Cabrera C, Struebig M, Barnes M, Terry A, Kaneko M, Shintani Y, Coppen S, Shiratori H, Ameen T, Mein C, Hamada H, Suzuki K, Yashiro K.
Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo.
PLoS One. 2015 Oct 15;10(10):e0140831. doi: 10.1371/journal.pone.0140831. eCollection 2015.

Yan Y, Tsukamoto O, Nakano A, Kato H, Kioka H, Ito N, Higo S, Yamazaki S, Shintani Y, Matsuoka K, Liao Y, Asanuma H, Asakura M, Takafuji K, Minamino T, Asano Y, Kitakaze M, Takashima S.
Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5.
Nat Commun. 2015 Jan 30;6:6137. doi: 10.1038/ncomms7137.

Hayashi T, Asano Y, Shintani Y, Aoyama H, Kioka H, Tsukamoto O, Hikita M, Shinzawa-Itoh K, Takafuji K, Higo S, Kato H, Yamazaki S, Matsuoka K, Nakano A, Asanuma H, Asakura M, Minamino T, Goto Y, Ogura T, Kitakaze M, Komuro I, Sakata Y, Tsukihara T, Yoshikawa S, Takashima S.
Higd1a is a positive regulator of cytochrome c oxidase.
Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1553-8. doi: 10.1073/pnas.1419767112. Epub 2015 Jan 20.

 

Fukuda M, Aoki T
Molecular basis for the intracranial aneurysm formation.
Acta Neurochirurgica Supplement 2015;120:13-15

Aoki T
Inflammation mediates the pathogenesis of cerebral aneurysm and becomes therapeutic target.
Neuroimmunology and Neuroinflammation 2(2); 86-92, 2015

Xiaojun Ma, Tomohiro Aoki, Tatsuaki Tsuruyama, Shuh Narumiya
Definition of Prostaglandin E2-EP2 signals in the colon tumor microenvironment
that amplify inflammation and tumor growth.
Cancer Research 75(14):2822-32, 2015.doi: 10.1158/0008-5472.CAN-15-0125

 

2014

Tano N, Narita T, Kaneko M, Ikebe C, Coppen SR, Campbell NG, Shiraishi M, Shintani Y, Suzuki K.
Epicardial placement of mesenchymal stromal cell-sheets for the treatment of ischemic cardiomyopathy; in vivo proof-of-concept study.
Mol Ther. 2014 Oct;22(10):1864-71. doi: 10.1038/mt.2014.110. Epub 2014 Jun 16.

Shintani Y, Drexler HC, Kioka H, Terracciano CM, Coppen SR, Imamura H, Akao M, Nakai J, Wheeler AP, Higo S, Nakayama H, Takashima S, Yashiro K, Suzuki K.
Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2.
EMBO Rep. 2014 Apr;15(4):438-45. doi: 10.1002/embr.201337945. Epub 2014 Mar 7.

Kioka H, Kato H, Fujikawa M, Tsukamoto O, Suzuki T, Imamura H, Nakano A, Higo S, Yamazaki S, Matsuzaki T, Takafuji K, Asanuma H, Asakura M, Minamino T, Shintani Y, Yoshida M, Noji H, Kitakaze M, Komuro I, Asano Y, Takashima S.
Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation.
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):273-8. doi: 10.1073/pnas.1318547111. Epub 2013 Dec 16.

 

Tsuji K, Aoki T, Fukuda M, Nozaki K
Statins as a candidate of drugs for intracranial aneurysm treatment.
Health, 2014,6

Tsuji K, Nozaki K, Aoki T
NF-kB as a crucial factor for intracranial aneurysm formation and
the potential of Statins as drugs for intracranial aneurysm treatment through their anti-NF-kB effect.
OA inflammation 2(1):1, 2014

 

2013

Kaneko M, Shintani Y, Narita T, Ikebe C, Tano N, Yamahara K, Fukushima S, Coppen SR, Suzuki K.
Extracellular high mobility group box 1 plays a role in the effect of bone marrow mononuclear cell transplantation for heart failure.
PLoS One. 2013 Oct 18;8(10):e76908. doi: 10.1371/journal.pone.0076908. eCollection 2013..

Shintani Y, Kapoor A, Kaneko M, Smolenski RT, D’Acquisto F, Coppen SR, Harada-Shoji N, Lee HJ, Thiemermann C, Takashima S, Yashiro K, Suzuki K.
TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons.
Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5109-14. doi: 10.1073/pnas.1219243110. Epub 2013 Mar 11.

Narita T, Shintani Y, Ikebe C, Kaneko M, Campbell NG, Coppen SR, Uppal R, Sawa Y, Yashiro K, Suzuki K.
The use of scaffold-free cell sheet technique to refine mesenchymal stromal cell-based therapy for heart failure.
Mol Ther. 2013 Apr;21(4):860-7. doi: 10.1038/mt.2013.9. Epub 2013 Jan 29.

Narita T, Shintani Y, Ikebe C, Kaneko M, Harada N, Tshuma N, Takahashi K, Campbell NG, Coppen SR, Yashiro K, Sawa Y, Suzuki K.
The use of cell-sheet technique eliminates arrhythmogenicity of skeletal myoblast-based therapy to the heart with enhanced therapeutic effects.
Int J Cardiol. 2013 Sep 20;168(1):261-9. doi: 10.1016/j.ijcard.2012.09.081. Epub 2012 Oct 6.

 

Aoki T, Fukuda M, Narumiya S
Chronic inflammation in intracranial aneurysm formation.
Inflammation and Regeneration 2013;33(5):283-287

Sadanori Watanabe, Tihana De an, Toshimasa Ishizaki, Shingo Yasuda, Hiroshi Kamijyo, Daisuke Yamada, Tomohiro Aoki, Hiroshi Kiyonari, Hiroshi Kaneko, Ritsuko Shimizu, Masayuki Yamamoto, Gohta Goshima, Shuh Narumiya
Loss of a Rho-Regulated Actin Nucleator, mDia2, impairs Cytokinesis during Mouse Fetal Erythropoiesis.
Cell Reports 2013; 5(4):926-932

Yoshimura Y, Murakami Y, Saitoh M, Yokoi T, Aoki T, Miura K, Ueshima H, Nozaki K; SSS Research Group
Statin Use and Risk of Cerebral Aneurysm Rupture: A Hospital-Based Case-Control Study in Japan.
J Stroke Cerebrovasc Dis. 2013;23(2):343-348

 

2012

Brouilette S, Kuersten S, Mein C, Bozek M, Terry A, Dias KR, Bhaw-Rosun L, Shintani Y, Coppen S, Ikebe C, Sawhney V, Campbell N, Kaneko M, Tano N, Ishida H, Suzuki K, Yashiro K.
A simple and novel method for RNA-seq library preparation of single cell cDNA analysis by hyperactive Tn5 transposase.
Dev Dyn. 2012 Oct;241(10):1584-90. doi: 10.1002/dvdy.23850. Epub 2012 Aug 28

 

Aoki T, Narumiya S
Prostaglandins and chronic inflammation.
Trends in Pharmacological Sciences 2012; 33(6): 304-311.

R.Ishibashi*, T.Aoki*, M.Nishimura, S.Miyamoto
Imidapril inhibits cerebral aneurysm formation in an angiotensin-converting enzyme-independent, and matrix metalloproteinase-9-dependent manner.
Neurosurgery 2012;70(3): 722-730

T.Aoki, H.Kataoka, M.Nishimura, R.Ishibashi, R.Morishita, S.Miyamoto
Regression of intracranial aneurysms by simultaneous inhibition of NF-B and ets with chimeric decoy oligodeoxynucleotide treatment.
Neurosurgery 2012;70(6): 1534-1543

 

2011

Felkin LE, Narita T, Germack R, Shintani Y, Takahashi K, Sarathchandra P, López-Olañeta MM, Gómez-Salinero JM, Suzuki K, Barton PJ, Rosenthal N, Lara-Pezzi E.
Calcineurin splicing variant calcineurin Aβ1 improves cardiac function after myocardial infarction without inducing hypertrophy.
Circulation. 2011 Jun 21;123(24):2838-47. doi: 10.1161/CIRCULATIONAHA.110.012211. Epub 2011 May 31.

 

Aoki T, Nishimura M
The underlying mechanisms of cerebral aneurysm formation revealed by animal
models.
Journal of Biomedicine and biotechnology; Special Issue; Animal model of human pathology. 2011; Volume 2011: Article ID 535921

T.Aoki, M.Nishimura, H.Kataoka, R Ishibashi, K.Nozaki, S.Miyamoto
Complementary inhibition of cerebral aneurysm formation by eNOS and nNOS.
Laboratory Investigation 2011;91(4):619-26

M. Gomi, T. Aoki, Y. Takagi, M. Nishimura, Y. Ohsugi, M. Mihara, K. Nozaki, N. Hashimoto, S. Miyamoto, J. Takahashi
Single and local blockade of IL-6 signaling promotes neuronal differentiation from
transplanted embryonic stem cell-derived neural precursor cells.
J.Neuroscience Res. 2011;89(9):1388-99

T. Aoki, M. Nishimura, T. Matsuoka, K. Yamamoto, T. Furuyashiki, H. Kataoka, S. Kitaoka, R. Ishibashi, A. Ishibazawa, S. Miyamoto, R. Morishita, J. Ando, N. Hashimoto, K. Nozaki, S. Narumiya
PGE2-EP2 signaling in endothelium is activated to hemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-kB.
Br J Pharmacol. 2011;163(6):1237-1249

T.Mitsumori*, T.Furuyashiki*, T.Momiyama, A.Nishi, T.Shuto, T.Hayakawa, F.Ushikubi, S.Kitaoka, T.Aoki, H.Inoue, T.Matsuoka, S.Narumiya
Thromboxane receptor activation enhances striatal dopamine release, leading to
suppression of GABAergic transmission and enhanced sugar intake.
Eur.J.Neuroscience. 2011;34(4): 594-604

Y.Takagi, K.Kikuta, T.Moriwaki, T. Aoki, K.Nozaki, N.Hashimoto, S.Miyamoto
Expression of thioredoxin-1 and hypoxia inducible factor-1a in cerebral arteriovenous malformations: Possible role of redox regulatory factor in neoangiogenic property.
Surg.Neurol.Int. 2011;2:61

 

2010

Lovell MJ, Yasin M, Lee KL, Cheung KK, Shintani Y, Collino M, Sivarajah A, Leung KY, Takahashi K, Kapoor A, Yaqoob MM, Suzuki K, Lythgoe MF, Martin J, Munroe PB, Thiemermann C, Mathur A
Bone marrow mononuclear cells reduce myocardial reperfusion injury by activating the PI3K/Akt survival pathway..
Atherosclerosis. 2010 Nov;213(1):67-76. doi: 10.1016/j.atherosclerosis.2010.07.045. Epub 2010 Aug 4.

Kapoor A, Shintani Y, Collino M, Osuchowski MF, Busch D, Patel NS, Sepodes B, Castiglia S, Fantozzi R, Bishop-Bailey D, Mota-Filipe H, Yaqoob MM, Suzuki K, Bahrami S, Desvergne B, Mitchell JA, Thiemermann C.
Protective role of peroxisome proliferator-activated receptor-β/δ in septic shock.
Am J Respir Crit Care Med. 2010 Dec 15;182(12):1506-15. doi: 10.1164/rccm.201002-0240OC. Epub 2010 Aug 6.

Nakano A, Kato H, Watanabe T, Min KD, Yamazaki S, Asano Y, Seguchi O, Higo S, Shintani Y, Asanuma H, Asakura M, Minamino T, Kaibuchi K, Mochizuki N, Kitakaze M, Takashima S.
AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation.
Nat Cell Biol. 2010 Jun;12(6):583-90. doi: 10.1038/ncb2060. Epub 2010 May 23.

 

Aoki T, Nishimura M
Targeting chronic inflammation in cerebral aneurysms focusing on NFkB as a putative target of medical therapy.
Expert Opinion on therapeutic Targets. 2010 Mar 14(3):265-273

Aoki T, Nishimura M
Targeting chronic inflammation in cerebral aneurysms focusing on NFkB as a putative target of medical therapy.
Expert Opinion on therapeutic Targets. 2010 Mar 14(3):265-273

Aoki T, Nishimura M
Molecular mechanism of cerebral aneurysm formation focused on NF-kB as a key
mediator of inflammation.
Journal of Biorheology 2010;24:16-21

T.Aoki, M.Nishimura, R Ishibashi, H.Kataoka, Y.Takagi, N.Hashimoto
Toll like receptor 4 expression during cerebral aneurysm formation.
Journal of Neurosurgery 2010;113(8):851-8

T.Aoki, H.Kataoka, M.Nishimura, R.Ishibashi, R.Morishita, S.Miyamoto
Ets-1 promotes the progression of cerebral aneurysm by inducing the expression of MCP-1 in vascular smooth muscle cells.
Gene Therapy 2010;17(9):1117-23

R.Ishibashi*, T.Aoki*, M.Nishimura, N.Hashimoto, S.Miyamoto
Contribution of Mast Cells to Cerebral Aneurysm Formation.
Current Neurovascular Research 2010;7(2):113-24